Precise CNS Delivery

Effective drug delivery is paramount in preclinical studies across various modalities. It serves as a critical bridge between promising therapeutic candidates and their potential clinical applications.

NeuroPhys Solutions leverages state-of-the-art technology, proprietary techniques, and decades of preclinical development experience to provide unparalleled precision and quality in drug delivery. Our commitment to quality and precision ensures that each study yields meaningful and reproducible data, saving our partners precious time and money.

Intraparenchymal (IPa)

Intraparenchymal delivery is a route of administration that involves delivering a substance directly into the brain parenchyma. This method can help achieve high drug concentrations at the target site and avoid the blood-brain barrier (BBB).
Intra Cerebroventricular (ICV)

Intracerebroventricular (ICV) injections are used to introduce compounds, drugs, and other agents into the central nervous system (CNS) of rodents. ICV injections can bypass the blood-brain barrier (BBB) and allow high concentrations of drugs to reach the brain's central compartment.
Intra Cisterna Magna (ICM)

Intra cisterna magna (ICM) delivery is a method of injecting a therapeutics into the cerebrospinal fluid (CSF)-filled subarachnoid space between the cerebellum and the dorsal side of the medulla oblongata. ICM is less invasive than ICV, allowing for delivery directly to the spinal canal or subarachnoid space without interference with any CNS tissue, making its repeated delivery possible.
IntraThecal (IT)

Intrathecal delivery involves the administration of drugs directly into the cerebrospinal fluid (CSF) within the spinal canal. This method bypasses the blood-brain barrier, allowing for targeted delivery of therapeutic agents to the central nervous system (CNS). By administering drugs intrathecally, researchers can achieve higher local concentrations of the drug in the CNS, enhancing therapeutic efficacy and reducing systemic side effects.
Acute/Chronic Infusions - Cannula Implantation, Osmotic Pumps

Acute Infusions: These involve a single or short-term administration of a drug or other substance. This method is typically used to study immediate effects, such as drug pharmacodynamics, acute toxicity, or rapid therapeutic responses. Acute infusions are often delivered via specialized cannula implants into the target region. Chronic Infusions: In contrast, chronic infusions involve long-term administration, which can span days, weeks, or even months. This approach is used to study the effects of prolonged exposure to a substance, such as in the evaluation of potential treatments for chronic neurological diseases, long-term toxicity, and the progression of neurodegenerative conditions. Chronic infusions are typically administered through implanted devices, like osmotic minipumps, that provide a continuous and controlled release of the substance into the CNS.
Convection enhanced delivery (CED)

Convection-enhanced delivery is a method for delivering therapeutic agents to large areas of the brain using bulk flow to increase hydrostatic pressure and improve volume distribution

We deliver a wide variety of sponsor tailored drug products via one or more delivery methods including:

Viral Drug Products: Gene Therapy, Gene Editing, ASOs, SiRNAs
Small Molecules/Biologics
Nanoparticles
mAbs
Cell Transplants